Ledifos — Sofosbuvir 400 mg / Ledipasvir 90 mg
Ledifos is a fixed-dose combination antiviral medication for Hepatitis C. Active ingredients: Sofosbuvir (400 mg) + Ledipasvir (90 mg).
Manufacturer: Hetero Healthcare (India). It is a licensed generic of the blockbuster drug Harvoni.
Why choose Ledifos:
It offers a cure for Hepatitis C Genotype 1 without the need for interferon or ribavirin injections. The treatment is simple, safe, and highly effective.
✅ Success Rate: SVR (Sustained Virologic Response) rates of 95-99%.
Indicated for the treatment of chronic Hepatitis C Genotype 1 (1a and 1b) and Genotype 4.
Suitable for:
- Patients with or without compensated cirrhosis.
- Treatment-naive patients.
- Treatment-experienced patients (who failed prior interferon therapy).
Dosage: One tablet taken orally once daily.
Treatment Duration:
- 12 Weeks: Standard for most patients.
- 24 Weeks: Recommended for treatment-experienced patients with cirrhosis.
⚠️ DRUG INTERACTIONS:
- 💊 Antacids/PPIs: Medications like Omeprazole reduce drug absorption. Take Ledifos 4 hours before or after these drugs.
- Can be taken with or without food.
🚫 DANGEROUS INTERACTION: AMIODARONE.
Co-administration with Amiodarone can cause serious symptomatic bradycardia (slow heart rate) or fatal cardiac arrest.
Other Contraindications:
- Pregnancy and breastfeeding.
- Children under 12 years (or < 35 kg).
- Co-administration with St. John’s wort or Rosuvastatin (high doses).
Generally very well tolerated. Most common adverse reactions are mild:
- Fatigue.
- Headache.
- Hepatitis B Reactivation: Patients coinfected with HBV may experience a flare-up. Screening for Hepatitis B is mandatory before starting therapy.
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