Empagliflozin: Drug for Diabetes & Heart Failure
Empagliflozin is a pharmaceutical drug belonging to the sodium-glucose co-transporter-2 (SGLT2) inhibitors class. Its mechanism is unique: it blocks the reabsorption of glucose in the kidneys, causing excess sugar to be excreted from the body via urine.
Beyond glycemic control, Empagliflozin has proven effective in protecting the heart and kidneys, significantly reducing the risk of hospitalization and cardiovascular death. On Unifarm, you can find original medications (e.g., Jardiance) and generics containing this active ingredient.
Indications
- Type 2 Diabetes Mellitus: To improve glycemic control (as monotherapy or combined with metformin/insulin).
- Chronic Heart Failure: To reduce the risk of cardiovascular death and hospitalization (regardless of diabetes status).
- Chronic Kidney Disease: To slow the progression of kidney failure.
Dosage and administration
The medication is taken orally once daily, preferably in the morning. Intake is independent of meals.
Recommended Regimen:
- Starting Dose: 10 mg once daily.
- Dose Adjustment: Can be increased to 25 mg once daily if additional glycemic control is needed and the drug is well tolerated.
- Patients are advised to maintain adequate hydration to prevent volume depletion.
- Type 1 Diabetes Mellitus (due to risk of diabetic ketoacidosis).
- Severe renal impairment (End-stage renal disease, Dialysis).
- Pregnancy and breastfeeding (safety not established).
- Age under 18 years.
- Hypersensitivity to Empagliflozin.
Due to glucose excretion in urine, specific adverse reactions may occur:
- Infections: Genital mycotic infections (vaginal moniliasis, balanitis), urinary tract infections (UTIs).
- Metabolic: Hypoglycemia (when used with insulin), dehydration, increased thirst.
- Cardiovascular: Hypotension (low blood pressure).
- Rare: Diabetic ketoacidosis (a serious condition requiring immediate medical attention).
List of medicines by active substance Empagliflozin
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