Vesanoid (Tretinoin) 10 mg
Vesanoid is the original brand of Tretinoin (10 mg), also known as All-trans Retinoic Acid (ATRA).
Manufacturer: Roche / Cheplapharm.
Mechanism: Differentiation Therapy
Unlike traditional chemotherapy that kills cells, Vesanoid works by forcing immature cancer cells (promyelocytes) to mature (differentiate) into normal, functioning blood cells. This unique mechanism has turned a once-fatal leukemia into a highly curable disease.
✅ Clinical Status: The standard of care for induction remission in APL.
Indicated for the induction of remission in patients with:
- Acute Promyelocytic Leukemia (APL): Characterized by the t(15;17) translocation. Used for both newly diagnosed and relapsed patients.
Strength: 10 mg soft gelatin capsule.
Standard Dosage: 45 mg/m²/day administered in two evenly divided doses.
⚠️ Administration Instructions:
- 🍲 Take with food. Absorption is significantly enhanced by food.
- Do not crush or chew.
- Therapy usually continues for 30 to 90 days until complete remission is achieved.
🚫 BLACK BOX WARNING: PREGNANCY.
There is an extremely high risk that Tretinoin will cause severe birth defects if pregnancy occurs while taking it. Effective contraception is mandatory for all patients of childbearing potential.
Drug Interactions:
- Do NOT take with Vitamin A supplements (risk of hypervitaminosis A).
- Do NOT take with Tetracyclines (risk of pseudotumor cerebri/intracranial hypertension).
Critical Warning: Retinoic Acid Syndrome (RAS).
Watch for fever, dyspnea (shortness of breath), weight gain, or edema. This condition can be fatal if not treated immediately with corticosteroids.
Other common effects:
- Dry skin, chapped lips (Cheilitis), dry eyes.
- Headache (severe headaches may indicate intracranial pressure).
- Bone pain.
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