Taxeleon (Paclitaxel) 300 mg/50 ml Injection Vial
Taxeleon 300 mg is a high-volume concentrate for infusion containing Paclitaxel (300 mg / 50 ml).
Manufacturer: Neon Laboratories (India).
⚠️ DOSAGE ALERT: 300 MG VIAL
This is the 300 mg "Pharmacy Bulk Package". It is designed for adult patients requiring full standard doses (e.g., 175 mg/m²). For an average adult, one 300 mg vial is often sufficient for a complete single treatment cycle, eliminating the need to open multiple smaller 100 mg vials.
✅ Benefit: Improves preparation efficiency and reduces medical waste.
Indicated for high-dose chemotherapy regimens:
- Ovarian Cancer: First-line and subsequent therapy.
- Breast Cancer: Metastatic disease or adjuvant treatment.
- Non-Small Cell Lung Cancer (NSCLC).
- Kaposi's Sarcoma.
Vial Strength: 300 mg (50 ml).
Must be diluted prior to infusion. Final concentration should be between 0.3 and 1.2 mg/ml.
⚠️ CRITICAL SAFETY PROTOCOLS:
- 🚫 NON-PVC Equipment: Do NOT use standard PVC tubing or bags. The solvent (Cremophor EL) leaches plasticizers. Use glass or polyolefin containers.
- ⚙️ In-line Filter: Administer through a 0.22-micron filter to catch potential precipitates.
- 💉 Mandatory Pre-medication: Corticosteroids and antihistamines must be given prior to infusion to prevent hypersensitivity reactions.
- Baseline Neutropenia (Neutrophil count < 1,500/mm³).
- Severe hypersensitivity to Paclitaxel or polyoxyl 35 castor oil.
- Pregnancy and breastfeeding.
- Concurrent serious infections.
Common adverse reactions:
- Alopecia: Almost universal hair loss (reversible).
- Myalgia/Arthralgia: Severe muscle and joint pain occurring 2-3 days post-treatment.
- Neuropathy: Numbness and tingling in extremities.
- Hypersensitivity reactions (flushing, dyspnea).
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