Renaxen 5 Tablets — Axitinib 5 mg (60 Tabs) Everest
Renaxen 5 mg (Axitinib) is a potent and selective tyrosine kinase inhibitor targeting vascular endothelial growth factor receptors (VEGFR-1, -2, and -3). It serves as a cost-effective generic equivalent to Inlyta. By inhibiting these receptors, Axitinib blocks angiogenesis (the formation of new blood vessels), effectively starving the tumor of nutrients and oxygen.
Manufacturer: Everest Pharmaceuticals (Bangladesh). The 5 mg strength represents the standard starting dose for the treatment of advanced renal cell carcinoma.
Key Features:
- ✅ Anti-Angiogenic Mechanism: Directly halts the blood supply to the tumor, inhibiting its growth.
- ✅ Advanced RCC Standard: Proven efficacy in treating kidney cancer after failure of prior systemic treatments.
- ✅ Monthly Supply: The box is designed to cover exactly one month of treatment at the standard dosage.
Prescribed by oncologists for the treatment of adult patients with:
- 🔹 Advanced Renal Cell Carcinoma (RCC): Specifically indicated after failure of one prior systemic therapy (e.g., sunitinib or cytokine-based regimens).
Sales Unit: Box containing 60 film-coated tablets (5 mg strength). This provides exactly a 30-day supply.
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 5 mg (one tablet) taken orally twice daily.
- Administration: Take doses approximately 12 hours apart. Can be taken with or without food. Swallow whole with a full glass of water. Do not crush or chew.
- ✋ Missed Dose: If a dose is missed or vomiting occurs, do not take an extra dose. Resume the regular schedule at the next time.
- Adjustment: Dosage may be titrated by the physician based on individual safety and tolerability.
- ⛔ Pregnancy & Breastfeeding: Strictly contraindicated. Can cause fetal harm.
- Hypersensitivity to Axitinib.
- Severe hepatic impairment (Child-Pugh Class C).
- History of arterial thromboembolic events (stroke, heart attack) within the last 12 months.
- Uncontrolled hypertension.
Blood pressure and thyroid function must be monitored regularly. Potential side effects include:
- 📈 Hypertension: High blood pressure (very common).
- 🤢 Gastrointestinal: Diarrhea, nausea, vomiting, decreased appetite.
- 🗣️ Dysphonia: Hoarseness or voice changes.
- 🦋 Thyroid: Hypothyroidism (low thyroid hormone levels).
- ✋ Skin: Hand-Foot Syndrome (Palmar-plantar erythrodysesthesia).
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