Lenvaxen 4 (Lenvatinib) 4 mg Capsules
Lenvaxen 4 mg (Lenvatinib) is a multiple receptor tyrosine kinase inhibitor utilized for targeted cancer therapy.
Manufacturer: Everest Pharmaceuticals. Each pack contains 30 capsules. It functions by inhibiting angiogenesis (blood vessel formation) and tumor growth by blocking specific receptors including VEGFR, FGFR, and RET.
Dosage flexibility:
The 4 mg capsule strength allows for precise dose adjustments, which is critical for patients with liver cancer or those requiring dose reductions due to toxicity.
Indicated for the treatment of adult patients with:
- 🔹 Hepatocellular Carcinoma (HCC): First-line treatment for unresectable liver cancer.
- 🔹 Differentiated Thyroid Cancer (DTC): Locally recurrent or metastatic, progressive, radioactive iodine-refractory DTC.
- 🔹 Renal Cell Carcinoma (RCC): In combination with everolimus for advanced kidney cancer.
- 🔹 Endometrial Carcinoma: In combination with pembrolizumab for advanced endometrial carcinoma.
Packaging: 4 mg capsules.
⚠️ ADMINISTRATION PROTOCOL (For HCC/Liver Cancer):
- Weight-based dosing:
— Body weight ≥ 60 kg: 12 mg (3 capsules) once daily.
— Body weight < 60 kg: 8 mg (2 capsules) once daily. - For Thyroid Cancer (DTC): Recommended dose is 24 mg (6 capsules) once daily.
- Timing: Take orally once daily, at the same time each day, with or without food.
- Administration: Swallow whole. Do not open, crush, or chew the capsule.
- Hypersensitivity to Lenvatinib.
- Pregnancy and breastfeeding (teratogenic effects).
- Severe hepatic impairment (Child-Pugh C) or severe renal impairment require careful monitoring.
Common adverse reactions include:
- 🩸 Cardiovascular: Hypertension (high blood pressure) is very common; proteinuria.
- 📉 Dermatologic: Palmar-plantar erythrodysesthesia (Hand-Foot Syndrome) — redness/pain on palms and soles.
- 🌀 Gastrointestinal/General: Diarrhea, fatigue, decreased appetite, weight loss, dysphonia (hoarseness).
- Patients should monitor blood pressure regularly.
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