Enzamide Tablets — Enzalutamide 40 mg (30 Tabs) Everest
Enzamide 40 mg (Enzalutamide) is a potent non-steroidal antiandrogen (androgen receptor inhibitor) and a generic equivalent to Xtandi. It is specifically indicated for the treatment of prostate cancer. The drug works by blocking testosterone from binding to prostate cancer cells, effectively starving the tumor and inhibiting its growth, even when other hormonal therapies have failed.
Manufacturer: Everest Pharmaceuticals (Bangladesh). It helps delay disease progression and the need for chemotherapy.
Key Features:
- ✅ Triple Action: Inhibits androgen binding, prevents nuclear translocation, and blocks DNA interaction within the cancer cell.
- ✅ Proven Efficacy: Significantly extends survival in patients with metastatic castration-resistant prostate cancer.
- ✅ Convenience: Once-daily oral dosing without the requirement for concurrent corticosteroids (unlike abiraterone).
Prescribed by oncologists for the treatment of adult men with:
- 🔹 Metastatic Castration-Resistant Prostate Cancer (mCRPC): For patients whose disease has progressed despite androgen deprivation therapy (both pre- and post-chemotherapy settings).
- 🔹 Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC): For patients at high risk of developing metastasis.
- 🔹 Metastatic Hormone-Sensitive Prostate Cancer (mHSPC).
Sales Unit: Bottle containing 30 film-coated tablets (40 mg strength).
⚠️ APPLICATION INSTRUCTIONS:
- Standard Daily Dosage: 160 mg (which equals 4 tablets of 40 mg) taken once daily.
- Administration: Take all 4 tablets at the same time, once a day. Can be taken with or without food.
- Method: Swallow tablets whole with water. Do not chew, dissolve, or break the tablets.
- ✋ Missed Dose: If you miss a dose, take it as soon as you remember on the same day. If you forget for the whole day, resume your normal schedule the next day. Do not take a double dose to make up for the missed one.
- ⛔ Women and Children: Strictly indicated for men only. Contraindicated in pregnant women (fetal toxicity).
- Hypersensitivity to Enzalutamide.
- History of Seizures: Use with caution (drug may lower seizure threshold).
- Severe renal impairment.
Patients are advised to maintain physical activity to manage fatigue. Potential side effects include:
- 💤 General: Fatigue (asthenia), weakness.
- 🥵 Vascular: Hot flushes (very common), hypertension (high blood pressure).
- 🦴 Musculoskeletal: Increased risk of falls and fractures.
- 🧠 Neurological: Headache, anxiety, memory impairment, rarely — seizures.
- 🤢 Gastrointestinal: Decreased appetite, constipation, or diarrhea.
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