Abiraxen Tablets — Abiraterone 250 mg (28 Tabs) Everest
Abiraxen 250 mg (Abiraterone Acetate) is a potent hormonal therapy for prostate cancer and a generic equivalent to Zytiga. It works by inhibiting the CYP17 enzyme, which is crucial for androgen biosynthesis. By blocking this enzyme, Abiraxen stops the production of testosterone — the hormone that drives prostate cancer growth — in the testes, adrenal glands, and the tumor itself.
Manufacturer: Everest Pharmaceuticals (Bangladesh). This drug is a cornerstone in the treatment of advanced prostate cancer.
Key Features:
- ✅ Comprehensive Inhibition: Blocks androgen production at all three sources (testes, adrenal glands, tumor tissue).
- ✅ Proven Efficacy: Significantly increases overall survival in patients with metastatic prostate cancer.
- ✅ Combination Use: Administered alongside prednisone to mitigate mineralocorticoid-related side effects.
Prescribed by oncologists for the treatment of adult men with:
- 🔹 Metastatic Castration-Resistant Prostate Cancer (mCRPC): For patients who are asymptomatic/mildly symptomatic or those whose disease has progressed on or after a docetaxel-based chemotherapy regimen.
- 🔹 Metastatic High-Risk Castration-Sensitive Prostate Cancer (mHSPC): In combination with androgen deprivation therapy (ADT).
Sales Unit: Film-coated tablets, 250 mg strength.
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 1000 mg (four 250 mg tablets) taken orally once daily.
- Critical Administration Rule: Take on an empty stomach. No food should be consumed for at least 2 hours before and 1 hour after the dose. Taking with food significantly increases absorption and risk of toxicity.
- 💊 Co-administration: Must be taken with low-dose prednisone or prednisolone as prescribed to manage fluid retention and hypertension.
- Method: Swallow tablets whole with water. Do not crush or chew.
- ⛔ Women & Pregnancy: Strictly contraindicated. Pregnant women should not even handle the tablets without protection (Category X).
- Hypersensitivity to Abiraterone Acetate.
- Severe hepatic impairment (liver failure).
- Pediatric use is not permitted.
Regular monitoring of blood pressure, serum potassium, and liver enzymes is mandatory. Potential side effects include:
- 💧 Fluid Retention: Peripheral edema (swelling of legs/feet).
- 🍌 Hypokalemia: Low blood potassium levels.
- 📈 Hypertension: High blood pressure.
- 🔶 Hepatotoxicity: Elevated liver enzymes (ALT/AST).
- 🚽 Infections: Urinary tract infections (UTI).
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