Abirapro (Abiraterone Acetate) 250 mg
Abirapro is an oral prescription medication used to treat prostate cancer. Active ingredient: Abiraterone Acetate (250 mg).
Manufacturer: Glenmark Pharmaceuticals (India). It is a cost-effective generic version of Zytiga.
Mechanism of Action:
Abirapro works by inhibiting the enzyme CYP17, which is responsible for androgen (testosterone) production. By stopping the production of testosterone in the testes, adrenal glands, and the tumor itself, it slows down the growth of cancer cells.
✅ Used in combination with prednisone or prednisolone.
Treatment of metastatic castration-resistant prostate cancer (mCRPC) in adult men.
It is indicated for:
- Patients whose disease has progressed on or after a docetaxel-based chemotherapy regimen.
- Patients who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated.
Recommended Dosage: 1,000 mg (4 tablets of 250 mg) taken orally once daily.
⚠️ CRITICAL INSTRUCTIONS:
- 🚫 Take on an empty stomach. No food should be consumed for at least 2 hours before and 1 hour after taking the dose.
- Taking Abirapro with food significantly increases absorption, which can lead to serious side effects.
- Swallow tablets whole with water.
Combination Therapy: Must be taken with low-dose prednisone or prednisolone (usually 5–10 mg daily) to reduce the risk of hypertension and fluid retention.
- Hypersensitivity to the active substance.
- Severe hepatic impairment (Child-Pugh Class C).
- Women who are or may become pregnant (Category X).
Warning: This medication is for men only. Women who are pregnant should not handle the tablets without protection (gloves).
Most mineralocorticoid side effects are managed by taking prednisone. Common reactions include:
- Peripheral edema (swelling of legs).
- Hypokalemia (low potassium levels).
- Hypertension (high blood pressure).
- Fatigue.
- Joint pain or discomfort.
Regular monitoring of blood pressure, serum potassium, and liver function is required.
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