Avapag Tablets — Avatrombopag 20 mg (28 Tabs) Everest
Avapag 20 mg (Avatrombopag) is a second-generation thrombopoietin receptor agonist (TPO-RA) and a generic equivalent to Doptelet. It mimics biological thrombopoietin to stimulate the proliferation and differentiation of megakaryocytes in the bone marrow, resulting in increased platelet production.
Manufacturer: Everest Pharmaceuticals (Bangladesh). It offers a reliable solution for raising platelet counts without the need for platelet transfusions or immunosuppression.
Key Features:
- ✅ Targeted Action: Specifically boosts platelet count to safe levels for surgeries or daily life.
- ✅ Oral Convenience: Tablet formulation taken with food.
- ✅ Dual Indication: Approved for both chronic liver disease (CLD) patients undergoing procedures and chronic immune thrombocytopenia (ITP).
Prescribed by hematologists/hepatologists for adult patients with:
- 🔹 Chronic Liver Disease (CLD): Treatment of thrombocytopenia in patients scheduled to undergo an invasive procedure (to reduce the need for platelet transfusions).
- 🔹 Chronic Immune Thrombocytopenia (ITP): Treatment of patients who have had an insufficient response to a previous treatment.
Sales Unit: Bottle containing 28 film-coated tablets (20 mg strength).
⚠️ APPLICATION INSTRUCTIONS:
- Administration: Take orally with food (essential for efficacy). Swallow whole.
- For CLD (Pre-procedure): Usually a 5-day course beginning 10-13 days before the scheduled procedure. Dosage (40 mg or 60 mg daily) depends on the baseline platelet count.
- For Chronic ITP: Starting dose is typically 20 mg once daily. The doctor will adjust the dose to maintain platelet counts ≥ 50×10⁹/L.
- ✋ Missed Dose: Take as soon as possible with food. Do not double the next dose.
- ⛔ Pregnancy & Breastfeeding: Not recommended due to potential fetal harm.
- Hypersensitivity to Avatrombopag.
- History of thromboembolic events (requires careful risk assessment).
- Pediatric patients (safety not established).
Monitoring of platelet counts is mandatory. Potential side effects include:
- ⚠️ Thromboembolism: Excessive platelet increase may cause blood clots. Seek help if you experience leg swelling, chest pain, or shortness of breath.
- 🤯 Neurological: Headache, fatigue.
- 🦴 Musculoskeletal: Joint pain (arthralgia).
- 🤢 Gastrointestinal: Nausea, abdominal pain.
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