Talaparib β Talazoparib 1 mg Capsules
26336β΄
28531β΄
-8%
Talaparib 1 mg (Talazoparib) is a potent PARP inhibitor and a generic equivalent to Talzenna. It is a targeted therapy designed to destroy cancer cells with BRCA gene mutations by blocking their DNA repair mechanisms.
Manufacturer: Everest Pharmaceuticals (Bangladesh). β οΈ Note: Contains 30 capsules per bottle. Designed for a full one-month course of treatment.
Key Features:
- β Targeted Mechanism: Utilizes "synthetic lethality" by inhibiting the PARP enzyme, causing DNA damage accumulation specifically in BRCA-mutated cancer cells, leading to their death.
- β Convenience: Once-daily oral capsule formulation (no infusions required).
- β Efficacy: Demonstrated significant improvement in progression-free survival and quality of life compared to standard chemotherapy.
Prescribed by oncologists typically after confirmation via a genetic test:
- πΉ Breast Cancer: Treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer.
Sales Unit: 1 Bottle (30 Capsules of 1 mg).
β οΈ ADMINISTRATION GUIDELINES:
- Standard Dosage: 1 mg (1 capsule) taken once daily. Ideally taken at the same time each day.
- How to take: Swallow the capsule whole with water. Can be taken with or without food.
- β Important: Do not open, crush, dissolve, or chew the capsules.
- Missed Dose or Vomiting: If you vomit or miss a dose, do NOT take an extra dose. Resume the regular schedule the next day.
- β Pregnancy and Breastfeeding: Can cause fetal harm. Effective contraception is mandatory during treatment and for 7 months after.
- Moderate to severe renal impairment (requires dose adjustment).
- Children (under 18 years of age).
- Hypersensitivity to Talazoparib.
Monthly blood tests are required to monitor for bone marrow suppression. Potential side effects:
- π©Έ Hematologic (Very Common): Anemia (low red blood cells), neutropenia (low white blood cells), thrombocytopenia (low platelets). Blood transfusions may be necessary.
- π General: Fatigue, weakness (asthenia).
- π€’ Gastrointestinal: Nausea, vomiting, decreased appetite.
- πββοΈ Skin: Alopecia (hair loss).
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