Selinex β Selinexor 20 mg Tablets
29409β΄
31603β΄
-7%
Selinex 20 mg (Selinexor) is a cutting-edge antitumor drug and a generic equivalent to Xpovio. It is a first-in-class Selective Inhibitor of Nuclear Export (SINE) compound that restores the body's natural tumor-suppressing mechanisms.
Manufacturer: Everest Pharmaceuticals (Bangladesh). The drug works by blocking the XPO1 protein, causing tumor suppressor proteins to accumulate within the cancer cell nucleus, triggering apoptosis (cell death).
Key Features:
- β Unique Mechanism: Unlike traditional chemotherapy, it prevents the cancer cell from expelling protective proteins from its nucleus, forcing them to fight the tumor.
- β Overcoming Resistance: Effective in patients whose cancer has stopped responding to other treatments (proteasome inhibitors, immunomodulators).
- β Synergy: Enhances the effect of other anticancer drugs, such as dexamethasone or bortezomib.
Prescribed by hematologists or oncologists for complex hematologic malignancies:
- πΉ Multiple Myeloma: For patients with relapsed or refractory disease who have received at least one prior therapy. Usually administered in combination with dexamethasone.
- πΉ Diffuse Large B-Cell Lymphoma (DLBCL): For adult patients with relapsed or refractory disease after at least two lines of systemic therapy.
Sales Unit: Bottle containing 16 tablets of 20 mg.
β οΈ DOSING AND SUPPORTIVE CARE:
- Dosing Schedule: The dose and specific days (usually once or twice weekly) are determined by the physician.
- Nausea Prevention: Prophylactic antiemetics (5-HT3 antagonists) are mandatory prior to taking Selinexor, as nausea is a very common side effect.
- Administration: Swallow tablets whole with water. Can be taken with or without food.
- β Important: Do not break, chew, or crush the tablets.
- β Pregnancy and Breastfeeding: Can cause fetal harm.
- Severe hyponatremia (critically low sodium levels).
- Active severe infections.
- Children (under 18 years of age).
- Hypersensitivity to Selinexor.
Weekly blood tests and sodium level monitoring are required. Potential side effects:
- π©Έ Thrombocytopenia: Low platelet count (risk of bleeding).
- π€’ Gastrointestinal: Nausea, vomiting, diarrhea, decreased appetite, and weight loss (nutritional support may be needed).
- π General: Severe fatigue (asthenia).
- π§ͺ Hyponatremia: Low sodium levels in the blood (may require salt tablets or IV fluids).
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