Megval (Melphalan) 50 mg
2858₴
3298₴
-13%
Megval-50 (Melphalan 50 mg) is a potent cytotoxic chemotherapy drug classified as an alkylating agent.
Manufacturer: Emcure Pharmaceuticals. A cost-effective injectable generic equivalent to Alkeran.
Mechanism of Action:
Melphalan works by damaging the DNA of cancer cells, preventing them from multiplying. It is historically one of the most effective drugs for treating plasma cell cancers.
✅ Key Use: Often used in "High-Dose" conditioning regimens prior to Hematopoietic Stem Cell Transplantation (HSCT).
Strictly for hospital use (Intravenous infusion):
- 🩸 Multiple Myeloma: Considered a cornerstone therapy for this condition.
- Advanced Ovarian Adenocarcinoma.
- Childhood Neuroblastoma.
- Used in regional arterial perfusion for localized malignant melanoma or soft tissue sarcoma of the extremities.
Form: Lyophilized Powder for Injection (50 mg vial).
⚠️ ADMINISTRATION WARNING:
- IV Only: Must be reconstituted and administered as a slow intravenous infusion.
- Dosing: Highly variable depending on the protocol (Standard vs. High-Dose Conditioning). Determined by Body Surface Area (BSA).
- Monitoring: Blood counts (CBC) must be checked frequently before each dose.
- Pregnancy and breastfeeding (Teratogenic).
- Severe bone marrow suppression (prior to treatment start).
- Hypersensitivity to Melphalan.
Being a cytotoxic agent, side effects are significant:
- 📉 Bone Marrow Suppression: Leukopenia (low white blood cells) and Thrombocytopenia (low platelets) are the dose-limiting toxicities.
- Gastrointestinal: Nausea, vomiting, diarrhea, and stomatitis.
- Alopecia: Hair loss is common with high doses.
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