Lazerib Tablets — Lazertinib 80 mg (90 Tabs) Everest
Lazerib 80 mg (Lazertinib) is a potent, highly selective, irreversible 3rd-generation EGFR tyrosine kinase inhibitor (TKI), serving as a generic equivalent to Leclaza. It specifically targets both activating EGFR mutations and the T790M resistance mutation while sparing wild-type EGFR.
Manufacturer: Everest Pharmaceuticals (Bangladesh). A key advantage of Lazertinib is its strong blood-brain barrier penetrability, providing efficacy against brain metastases.
Key Features:
- ✅ Overcoming Resistance: Highly effective against tumors harboring the T790M mutation, which causes resistance to earlier therapies.
- ✅ CNS Efficacy: Demonstrated significant activity in treating and preventing brain metastases in NSCLC patients.
- ✅ Better Tolerability: Low toxicity profile regarding skin and gastrointestinal issues compared to earlier generation TKIs.
Prescribed by oncologists for the treatment of adult patients with:
- 🔹 Non-Small Cell Lung Cancer (NSCLC): Locally advanced or metastatic NSCLC with confirmed EGFR mutations (Exon 19 deletion, L858R substitution) or T790M mutation.
Sales Unit: Bottle in a box containing 90 film-coated tablets (80 mg strength). This provides exactly a 30-day supply.
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 240 mg (three 80 mg tablets) taken orally once daily.
- Administration: Swallow tablets whole with water at the same time each day. Can be taken with or without food. Do not chew, crush, or split.
- ✋ Missed Dose: Take as soon as remembered unless the next dose is due within 12 hours. Do not take a double dose to make up for a missed one.
- ⛔ Pregnancy & Breastfeeding: Strictly contraindicated due to potential fetal harm.
- Hypersensitivity to Lazertinib.
- History of Interstitial Lung Disease (ILD) or pneumonitis.
- QT interval prolongation (heart rhythm disorder).
Regular cardiac monitoring (ECG) and lung assessments are recommended. Potential side effects include:
- ✋ Dermatologic: Paresthesia (tingling sensation), rash, pruritus, paronychia (nail infection).
- 🤢 Gastrointestinal: Decreased appetite, diarrhea, nausea.
- 💪 Musculoskeletal: Myalgia (muscle pain).
- 🤧 Respiratory: Dyspnea, cough (rarely pneumonitis).
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