Laronib 100 (Larotrectinib) 100 mg Capsules
39134₴
43971₴
-11%
Laronib 100 mg (Larotrectinib) is a potent, highly selective TRK inhibitor used for the treatment of cancers driven by specific genetic alterations.
Manufacturer: Everest Pharmaceuticals. Each pack contains 30 capsules. It is a precision oncology drug that targets tumors with NTRK gene fusions regardless of the tumor's location in the body (tissue-agnostic).
Key Feature:
This 100 mg capsule is the standard adult strength, offering deep and durable responses in patients with NTRK fusion-positive solid tumors.
Indicated for adult and pediatric patients with solid tumors that:
- 🔹 NTRK Fusion: Harbor a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion.
- 🔹 Condition: Are metastatic or where surgical resection involves severe morbidity, and there are no satisfactory alternative treatments.
- 🔹 Applicability: Broad range of cancers including sarcomas, lung cancer, thyroid cancer, and colon cancer.
Packaging: 100 mg capsules.
⚠️ ADMINISTRATION PROTOCOL:
- Standard Adult Dose: 100 mg orally twice daily.
- Usage: Take 1 capsule (100 mg) in the morning and 1 in the evening.
- Food Intake: Can be taken with or without food.
- Administration: Swallow whole with water. Do not chew or crush.
- Supply: One pack (30 caps) provides a 15-day supply at the standard dosage.
- Hypersensitivity to Larotrectinib.
- Pregnancy (can cause fetal harm).
- Breastfeeding (should be discontinued).
- Caution required with strong CYP3A4 inhibitors or inducers.
Common adverse reactions include:
- 🧠 Neurologic: Dizziness (very common), fatigue, paresthesia.
- 🩸 Hepatic: Increased liver enzymes (ALT/AST levels need monitoring).
- 📉 Gastrointestinal/Physical: Nausea, vomiting, constipation, weight gain.
- ⚠️ Advisory: Patients should avoid driving or operating machinery if they experience dizziness.
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