Ivosenib Tablets β Ivosidenib 250 mg (60 Tabs) Everest
118512β΄
127291β΄
-7%
Ivosenib 250 mg (Ivosidenib) is a targeted IDH1 inhibitor and a generic equivalent to Tibsovo. It works by blocking a specific enzyme mutation (IDH1), helping abnormal leukemia cells differentiate into normal, functioning blood cells.
Manufacturer: Everest Pharmaceuticals (Bangladesh). This medication represents a precision medicine approach for cancers driven by IDH1 mutations.
Key Features:
- β Differentiation Agent: Promotes the maturation of malignant myeloid cells rather than just killing them directly via cytotoxicity.
- β Targeted Action: Specifically designed for patients with a susceptible Isocitrate Dehydrogenase-1 (IDH1) mutation.
- β Dual Indication: Effective for both blood cancer (AML) and solid tumors (bile duct cancer).
Prescribed by specialists for adults with a susceptible IDH1 mutation:
- πΉ Acute Myeloid Leukemia (AML): For relapsed or refractory AML. Also as first-line treatment for patients β₯75 years or those ineligible for intensive chemotherapy.
- πΉ Cholangiocarcinoma: Previously treated, locally advanced or metastatic bile duct cancer.
Sales Unit: Bottle containing 60 film-coated tablets (250 mg strength).
β οΈ APPLICATION INSTRUCTIONS:
- Standard Dosage: Typically 500 mg (two 250 mg tablets) taken orally once daily at the same time.
- Administration: Swallow whole with water. Do not split, crush, or chew. Can be taken with or without food (avoid high-fat meals).
- Duration: Treatment typically continues as long as the patient derives clinical benefit (at least 6 months recommended for AML).
- β Missed Dose: If missed by more than 12 hours, skip the dose and resume the next day. Do not double up.
- β Cardiac Issues: Patients with Long QT syndrome or those taking medications that prolong the QT interval.
- Pregnancy and Breastfeeding: Can cause fetal harm.
- Pediatric patients (safety not established).
- Hypersensitivity to Ivosidenib.
- Severe hepatic impairment.
Requires strict medical supervision. Potential side effects include:
- β οΈ Differentiation Syndrome: A serious, potentially life-threatening condition (symptoms: fever, shortness of breath, rapid weight gain). Requires immediate medical attention.
- β€οΈ QTc Prolongation: Changes in heart rhythm visible on ECG.
- π Hematologic: Leukocytosis (high white blood cell count).
- π€’ General: Fatigue, joint pain (arthralgia), diarrhea, nausea.
100% original product
Delivery across Ukraine
Customer reviews
What Customers Say
No reviews yet
Your review can be the first!