Imaxen 400 Tablets β Imatinib 400 mg (14 Tabs) Everest
3731β΄
4609β΄
-19%
Imaxen 400 (Imatinib) is the "gold standard" first-generation tyrosine kinase inhibitor (TKI) and a generic equivalent to Gleevec (Glivec). It revolutionized cancer care by turning fatal leukemia into a manageable chronic condition.
Manufacturer: Everest Pharmaceuticals (Bangladesh). Imatinib works by inhibiting the Bcr-Abl tyrosine kinase, the abnormal protein driving the uncontrolled growth of cancer cells.
Key Features:
- β Targeted Therapy: Specifically seeks out and destroys cells containing the "Philadelphia chromosome" (Ph+) while sparing healthy cells.
- β Dual Action: Effective for both blood cancers and solid tumors like Gastrointestinal Stromal Tumors (GIST) by blocking c-KIT receptors.
- β Proven Safety: Extensive clinical history with a well-understood safety profile.
Prescribed by hematologists/oncologists for:
- πΉ Chronic Myeloid Leukemia (CML): For Philadelphia chromosome-positive (Ph+) CML in chronic, accelerated, or blast crisis phases.
- πΉ Acute Lymphoblastic Leukemia (ALL): Ph+ ALL usually in combination with chemotherapy.
- πΉ Gastrointestinal Stromal Tumors (GIST): For c-KIT positive unresectable and/or metastatic malignant tumors, or as adjuvant treatment after surgery.
Sales Unit: Bottle containing 14 film-coated tablets (400 mg strength).
β οΈ APPLICATION INSTRUCTIONS:
- How to Take: Take with a meal and a large glass of water (approx. 200ml) to minimize gastrointestinal irritation.
- Dosage: The recommended dose for chronic phase CML is 400 mg (1 tablet) once daily. Higher doses (600 mg or 800 mg) may be used in advanced stages.
- Administration: If unable to swallow, the tablet may be dispersed in a glass of water or apple juice (avoid grapefruit juice).
- β Consistency: Take at the same time every day.
- β Pregnancy & Breastfeeding: Contraindicated due to risk of fetal harm.
- Hypersensitivity to Imatinib.
- Children under 2 years of age.
- Severe hepatic or renal impairment (requires caution).
- Driving or operating machinery if dizziness or blurred vision occurs.
Side effects are generally manageable. Common reactions include:
- π Fluid Retention: Edema (swelling around eyes, ankles). Regular weight monitoring is advised.
- π€’ Gastrointestinal: Nausea, vomiting, diarrhea (mitigated by taking with food).
- 𦡠Musculoskeletal: Muscle cramps, bone or joint pain.
- π Skin: Rash, itching.
- π₯± Hematologic: Neutropenia or thrombocytopenia (low blood counts).
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