Ibruxen (Ibrutinib) Capsules
16709₴
18028₴
-7%
Ibruxen 140 mg (Ibrutinib) is a first-in-class Bruton's tyrosine kinase (BTK) inhibitor used to treat B-cell malignancies.
Manufacturer: Everest Pharmaceuticals. Each pack contains 120 capsules. By permanently binding to the BTK protein, it blocks the signaling pathway that allows abnormal B cells to survive and multiply.
Therapeutic Value:
It offers a chemotherapy-free treatment option for patients with chronic leukemias and lymphomas, often leading to durable responses.
Indicated for the treatment of adult patients with:
- 🔹 Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Including patients with 17p deletion.
- 🔹 Mantle Cell Lymphoma (MCL): For patients who have received at least one prior therapy.
- 🔹 Waldenström's Macroglobulinemia (WM): Indicated as a single agent or in combination with rituximab.
- 🔹 Marginal Zone Lymphoma (MZL): Relapsed or refractory cases.
Packaging: 140 mg capsules.
⚠️ ADMINISTRATION PROTOCOL:
- For CLL/SLL & Waldenström's: 420 mg (3 capsules) orally once daily.
- For Mantle Cell Lymphoma (MCL): 560 mg (4 capsules) orally once daily.
- Administration: Swallow capsules whole with water. Do not open, break, or chew.
- Missed Dose: If a dose is missed, it can be taken as soon as possible on the same day. Do not take extra capsules to make up for a missed dose.
- 🚫 Interaction: Avoid grapefruit and Seville oranges completely.
- Hypersensitivity to Ibrutinib.
- Pregnancy and breastfeeding (risk of fetal harm).
- Severe hepatic impairment (Child-Pugh Class C).
- Concomitant use with strong CYP3A inducers (e.g., St. John's Wort).
Common and serious adverse reactions include:
- 🩸 Cardiovascular/Hematic: Hemorrhage (bruising, bleeding), atrial fibrillation/flutter, hypertension.
- 📉 Infections: Pneumonia, upper respiratory tract infections.
- 🌀 Gastrointestinal: Diarrhea, nausea, stomatitis.
- ⚠️ Pre-surgery: Therapy should be withheld for at least 3 to 7 days pre- and post-surgery depending on the type of surgery and the risk of bleeding.
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