Hydrea Capsules β Hydroxyurea 500 mg (30 Caps) Everest
966β΄
1141β΄
-15%
Hydrea 500 mg (Hydroxyurea / Hydroxycarbamide) is a widely used antimetabolite antineoplastic agent. It works by inhibiting DNA synthesis in dividing cells, making it essential for managing myeloproliferative disorders.
Manufacturer: Everest Pharmaceuticals (Bangladesh). This medication is primarily used to reduce high platelet and white blood cell counts to prevent complications like thrombosis.
Key Features:
- β Blood Count Control: Rapidly lowers dangerous levels of blood cells in leukemia and related disorders.
- β Versatility: Effective for chronic blood cancers and as an adjunct to radiation therapy for certain solid tumors.
- β Oral Therapy: Convenient capsule form for outpatient management.
Prescribed by hematologists/oncologists for adult patients with:
- πΉ Chronic Myeloid Leukemia (CML): For resistant chronic phase or palliative control.
- πΉ Essential Thrombocythemia: To lower platelet counts and reduce thrombosis risk.
- πΉ Polycythemia Vera: To control red blood cell mass and blood viscosity.
- πΉ Head and Neck Cancer / Cervical Cancer: Used concurrently with radiation therapy to enhance its effectiveness (radiosensitizer).
Sales Unit: Bottle containing 30 capsules (500 mg strength).
β οΈ APPLICATION INSTRUCTIONS:
- Dosing: Strictly individualized based on the patient's actual or ideal body weight (typically 20β30 mg/kg daily).
- Administration: Swallow the capsule whole with water. Do not chew. Can be taken as a single dose or divided doses.
- Safety: The powder inside is cytotoxic. Do not open capsules. If powder spills, wipe up with a damp cloth immediately; avoid inhaling.
- β Monitoring: Weekly complete blood counts (CBC) are mandatory during the initiation of therapy.
- β Pregnancy & Breastfeeding: Strictly contraindicated due to risk of birth defects.
- Severe bone marrow depression: Leukopenia (< 2.5Γ10βΉ/L) or Thrombocytopenia (< 100Γ10βΉ/L).
- Severe anemia (must be corrected before starting treatment).
- Hypersensitivity to Hydroxyurea.
Bone marrow suppression is the dose-limiting toxicity. Potential side effects:
- π Hematologic: Leukopenia (infection risk), thrombocytopenia (bleeding risk), and anemia.
- π€’ Gastrointestinal: Nausea, vomiting, stomatitis (mouth sores).
- 𧬠Dermatologic: Skin dryness, hyperpigmentation (darkening), and rarely skin ulcers with long-term use.
- π¦ General: Fever, chills.
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