Hodpro — Procarbazine 50 mg
Hodpro is an oral antineoplastic agent containing Procarbazine Hydrochloride (50 mg).
Manufacturer: Neon Laboratories (India). It is a key component of the MOPP regimen used for Hodgkin's disease.
Special Characteristic:
Hodpro is a weak Monoamine Oxidase (MAO) inhibitor. It crosses the blood-brain barrier, making it useful for treating central nervous system tumors, but it also requires strict dietary restrictions due to food-drug interactions.
Indicated for the palliative treatment of generalized:
- Hodgkin’s Disease: Stages III and IV.
- Brain Tumors: Glioblastoma multiforme, medulloblastoma, and astrocytoma.
- Non-Hodgkin's Lymphomas.
Dosage: Usually 2-4 mg/kg/day initially, titrated by the oncologist.
⚠️ CRITICAL DIETARY RESTRICTIONS (Tyramine):
Because Hodpro inhibits MAO, consuming high-tyramine foods can cause a hypertensive crisis (sudden high blood pressure):
- 🧀 Avoid aged cheeses, yogurt, sour cream.
- 🍷 Avoid red wine, beer, and sherry.
- 🍌 Avoid ripe bananas, avocados, fava beans, and smoked meats.
🚫 ALCOHOL WARNING: Consuming alcohol while taking Hodpro causes a severe "Disulfiram-like reaction" (flushing, chest pain, difficulty breathing, vomiting). Strict abstinence is required.
- Pre-existing severe bone marrow depression.
- Hypersensitivity to procarbazine.
- Severe hepatic or renal impairment.
- Pregnancy and breastfeeding.
Common adverse reactions include:
- Gastrointestinal: Nausea and vomiting (very frequent), anorexia.
- CNS: Drowsiness, dizziness, depression, nightmares (avoid driving).
- Hematologic: Leukopenia, anemia, thrombocytopenia (delayed toxicity).
- Reproductive: Can cause azoospermia (sterility) in men.
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