Gilternib Tablets — Gilteritinib 40 mg (90 Tabs) Everest
54867₴
59256₴
-7%
Gilternib 40 mg (Gilteritinib) is a potent, second-generation FLT3 tyrosine kinase inhibitor and a generic equivalent to Xospata. It is designed to treat aggressive leukemia by targeting specific genetic mutations that drive cancer growth.
Manufacturer: Everest Pharmaceuticals (Bangladesh). Unlike older drugs, Gilteritinib inhibits both FLT3-ITD and FLT3-TKD mutations, offering a broader range of efficacy.
Key Features:
- ✅ Targeted Mechanism: Inhibits FLT3 and AXL receptor signaling, disrupting the proliferation of leukemic cells.
- ✅ Resistant Cases: Specifically formulated for patients whose cancer has returned after or did not respond to initial chemotherapy.
- ✅ Oral Therapy: Convenient tablet form for daily administration.
Prescribed by hematologists/oncologists for adult patients with:
- 🔹 Acute Myeloid Leukemia (AML): Relapsed or refractory AML with a confirmed FLT3 mutation.
Sales Unit: Bottle containing 90 film-coated tablets (40 mg strength). Typically, one bottle lasts for 30 days.
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 120 mg (3 tablets of 40 mg) taken orally once daily.
- Administration: Swallow tablets whole with water at the same time each day. Do not break or chew. Can be taken with or without food.
- Duration: Continue treatment as long as clinical benefit is observed or until hematopoietic stem cell transplantation (HSCT).
- ✋ Missed Dose: Take as soon as possible on the same day. Resume normal schedule the next day. Do not double the dose.
- ⛔ Pregnancy & Breastfeeding: Contraindicated. Can cause fetal harm. Effective contraception is mandatory.
- Hypersensitivity to Gilteritinib.
- Long QT Syndrome (history of).
- Pediatric patients (safety not established).
- Severe hepatic impairment.
Strict medical monitoring is required. Potential side effects include:
- ⚠️ Differentiation Syndrome: A serious condition (fever, dyspnea, fluid retention) caused by rapid cell maturation. Seek immediate medical help.
- 🩸 Liver: Elevated transaminases (ALT/AST).
- ❤️ Cardiac: QT interval prolongation (ECG monitoring needed).
- 📉 Hematologic: Anemia, thrombocytopenia.
- 🤢 General: Diarrhea, fatigue, muscle pain (myalgia).
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