Capixet Tablets β Capecitabine 500 mg (14 Tabs) Everest
Capixet 500 mg (Capecitabine) is an effective oral chemotherapy agent (cytostatic) and a generic equivalent to Xeloda. It acts as a prodrug that is enzymatically converted to 5-fluorouracil (5-FU) directly inside tumor cells, inhibiting DNA synthesis and slowing tumor growth.
Manufacturer: Everest Pharmaceuticals (Bangladesh). Due to its mechanism of activation, it achieves higher concentrations within the tumor while minimizing exposure to healthy tissues compared to traditional intravenous chemotherapy.
Key Features:
- β Targeted Activation: Activated by enzymes found in higher concentrations in tumors, reducing systemic toxicity.
- β Oral Convenience: Tablet formulation allows for home-based chemotherapy, avoiding the need for IV infusions.
- β Proven Efficacy: Widely used for colorectal, gastric, and breast cancers.
Prescribed by oncologists for the treatment of adult patients with:
- πΉ Colorectal Cancer: Adjuvant treatment of stage III colon cancer and metastatic colorectal cancer.
- πΉ Gastric Cancer: First-line treatment for advanced gastric cancer.
- πΉ Breast Cancer: Metastatic or locally advanced breast cancer (as monotherapy or combined with docetaxel) after failure of anthracycline-containing chemotherapy.
Sales Unit: Bottle containing 14 film-coated tablets (500 mg strength).
β οΈ APPLICATION INSTRUCTIONS:
- Dosage Calculation: Strictly prescribed by a doctor based on body surface area (BSA).
- Regimen: Typically taken twice daily (morning and evening) for 14 days, followed by a 7-day rest period.
- Administration: Swallow tablets whole with water within 30 minutes after a meal. Do not crush or chew (hazardous drug!).
- β Missed Dose: Do not take the missed dose at a later time and do not double the next dose. Continue with the regular schedule.
- β DPD Deficiency: Known complete absence of dihydropyrimidine dehydrogenase activity (risk of life-threatening toxicity).
- Pregnancy and Breastfeeding.
- Severe renal or hepatic impairment.
- Severe leukopenia, neutropenia, or thrombocytopenia.
Potential side effects may occur requiring monitoring:
- β οΈ Hand-Foot Syndrome: Redness, swelling, peeling, numbness, or pain on the palms of hands and soles of feet (characteristic of capecitabine).
- π€’ Gastrointestinal: Diarrhea (requires immediate management), nausea, vomiting, stomatitis (mouth sores), abdominal pain.
- π΄ General: Fatigue, asthenia (weakness).
- π©Έ Hematologic: Decreased white blood cell or platelet counts (risk of infection/bleeding).
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