Bendit (Bendamustine) 100 mg
Bendit 100 mg (Bendamustine Hydrochloride) is a potent alkylating antitumor agent with a unique chemical structure.
Manufacturer: Natco Pharma. Each vial contains 100 mg of lyophilized powder. It acts against cancer cells through a dual mechanism, disrupting DNA function and inducing apoptosis (cell death). It is widely used for hematological malignancies that are resistant to other therapies.
Mechanism of Action:
Bendamustine causes intra-strand and inter-strand cross-links between DNA bases. This extensive DNA damage prevents the cancer cells from replicating and repairing themselves.
✅ Benefit: Effective disease control in Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Indicated for the treatment of specific blood cancers:
- 🩸 Chronic Lymphocytic Leukemia (CLL): First-line treatment for patients not eligible for fludarabine combination therapy.
- 🎗️ Indolent Non-Hodgkin Lymphoma (NHL): For patients who have progressed during or following treatment with rituximab regimens.
- ☠️ Multiple Myeloma: Stage II/III (in combination with prednisone).
Packaging: Single Dose Vial (100 mg lyophilized powder).
⚠️ ADMINISTRATION PROTOCOL (IV Only):
- 🧪 Reconstitution: Dissolve powder in Sterile Water for Injection, then dilute in 0.9% Sodium Chloride (NaCl).
- 💉 Infusion: Administer as an intravenous infusion over 30–60 minutes. DO NOT push as a bolus.
- 📅 Regimen: Typically given on Days 1 and 2 of a 21 or 28-day cycle.
- 🛑 Extravasation: Ensure the needle is in the vein; leakage causes severe tissue damage.
- Severe hepatic impairment (liver damage).
- Severe myelosuppression (neutrophil count < 1,500/µL or platelets < 75,000/µL).
- Pregnancy and breastfeeding.
- Recent major surgery.
- Live virus vaccines (e.g., Yellow Fever vaccine).
Patients require close monitoring for:
- 🩸 Myelosuppression: Leukopenia, lymphopenia, and thrombocytopenia are very common.
- 🤢 Gastrointestinal: Nausea, vomiting, diarrhea.
- 🌡️ Pyrexia: Fever and fatigue often occur during infusion days.
- Skin reactions (rash).
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