Ascimib Tablets — Asciminib 40 mg (30 Tabs) Everest
Ascimib 40 mg (Asciminib) is a ground-breaking targeted therapy and the first-in-class STAMP inhibitor (Specifically Targeting the ABL Myristoyl Pocket). It is a generic equivalent to Scemblix. Unlike traditional tyrosine kinase inhibitors (TKIs) that bind to the ATP site, Ascimib binds to the myristoyl pocket, locking the BCR-ABL1 protein into an inactive conformation.
Manufacturer: Everest Pharmaceuticals (Bangladesh). Its unique mechanism allows it to work even when tumors have developed resistance to other treatments.
Key Features:
- ✅ Novel Mechanism: Acts as an allosteric inhibitor ("STAMP"), offering a new way to shut down cancer cell growth.
- ✅ Overcoming Resistance: Highly effective in patients who have failed multiple lines of previous TKI therapy.
- ✅ Selectivity: Designed to target the specific mutant protein, minimizing off-target effects.
Prescribed by hematologists for adult patients with:
- 🔹 Chronic Myeloid Leukemia (CML): In chronic phase (Ph+ CML-CP) previously treated with two or more tyrosine kinase inhibitors (e.g., imatinib, nilotinib, dasatinib).
- 🔹 T315I Mutation: Treatment of CML with the T315I mutation (requires different dosing strategies).
Sales Unit: Bottle containing 30 film-coated tablets (40 mg strength).
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: Typically 80 mg daily (taken as 40 mg twice daily approximately 12 hours apart, or 80 mg once daily, as prescribed).
- Fasting Requirement: Must be taken on an empty stomach. Avoid food for at least 2 hours before and 1 hour after taking the dose. Food significantly reduces absorption.
- Administration: Swallow tablets whole with water. Do not chew or crush.
- ✋ Missed Dose: If more than 6 hours have passed (for twice-daily regimen), skip the missed dose. Do not double up.
- ⛔ Pregnancy & Breastfeeding: Strictly contraindicated due to potential fetal harm.
- Hypersensitivity to Asciminib.
- History of pancreatitis (requires monitoring of pancreatic enzymes).
- Pediatric patients (safety not established).
Regular blood tests are required. Potential side effects include:
- 🩸 Hematologic: Thrombocytopenia (low platelets), neutropenia, anemia.
- 🦴 Musculoskeletal: Pain in muscles, joints, or bones.
- 🤯 General: Fatigue, headache.
- 🩺 Labs/Vitals: Elevated pancreatic enzymes (amylase/lipase), liver enzymes, hypertension.
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