Alkixen Capsules — Crizotinib 250 mg (60 Caps) Everest
17994₴
19750₴
-9%
AlkiXen 250 mg (Crizotinib) is a targeted cancer therapy, a tyrosine kinase inhibitor (TKI), and a generic equivalent to Xalkori. It works by blocking the activity of the ALK and ROS1 proteins, which drive the growth and spread of cancer cells in patients with specific genetic mutations.
Manufacturer: Everest Pharmaceuticals (Bangladesh). It is a standard-of-care medication for genetically defined subsets of lung cancer patients.
Key Features:
- ✅ Dual Inhibitor: Targets both Anaplastic Lymphoma Kinase (ALK) and ROS1 proto-oncogene receptor tyrosine kinase.
- ✅ Precision Medicine: Highly effective only in tumors carrying the specific ALK or ROS1 gene rearrangements.
- ✅ Oral Administration: Convenient capsule form for daily home use.
Prescribed by oncologists for the treatment of adult patients with:
- 🔹 Non-Small Cell Lung Cancer (NSCLC): Metastatic NSCLC that is ALK-positive as detected by an FDA-approved test.
- 🔹 ROS1-Positive NSCLC: Metastatic NSCLC with ROS1 gene alterations.
Sales Unit: Bottle containing 60 capsules (250 mg strength). Usually sufficient for a 1-month supply.
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 250 mg (one capsule) taken orally twice daily.
- Administration: Swallow capsules whole with water. Can be taken with or without food. Do not crush, dissolve, or open capsules.
- Grapefruit Warning: 🚫 Do not consume grapefruit or grapefruit juice during treatment (increases risk of toxicity).
- ✋ Missed Dose: Take as soon as remembered unless the next dose is due within 6 hours. Do not double up.
- ⛔ Pregnancy & Breastfeeding: Strictly contraindicated. Can cause fetal harm. Effective contraception is mandatory.
- Congenital Long QT Syndrome.
- Hypersensitivity to Crizotinib.
- Severe hepatic or renal impairment (dose adjustment required).
Monitoring is required. Potential side effects include:
- 👁️ Vision Disorders: Visual trails, flashes of light, or blurred vision (very common, usually mild).
- 🤢 Gastrointestinal: Nausea, vomiting, diarrhea, constipation.
- 💧 Edema: Swelling of hands, feet, or face.
- ❤️ Cardiac: Bradycardia (slow heart rate), QT prolongation on ECG.
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