Adakras Tablets — Adagrasib 200 mg (42 Tabs) Everest
Adakras 200 mg (Adagrasib) is a breakthrough targeted therapy and a highly selective inhibitor of the KRAS G12C mutation, acting as a generic equivalent to Krazati. For decades, KRAS was considered "undruggable," but Adagrasib irreversibly binds to the mutant protein, locking it in an inactive state and inhibiting tumor cell growth and viability.
Manufacturer: Everest Pharmaceuticals (Bangladesh). A distinct feature of this drug is its ability to penetrate the blood-brain barrier, offering efficacy against CNS metastases.
Key Features:
- ✅ Covalent Inhibition: Irreversibly blocks KRAS G12C signaling, halting cancer progression.
- ✅ CNS Penetration: Demonstrated clinical activity in treating brain metastases associated with NSCLC.
- ✅ Targeted Efficacy: Designed specifically for patients who have exhausted standard chemotherapy or immunotherapy options.
Prescribed by oncologists for the treatment of adult patients with:
- 🔹 Non-Small Cell Lung Cancer (NSCLC): KRAS G12C-mutated locally advanced or metastatic NSCLC, as determined by an approved test, who have received at least one prior systemic therapy.
Sales Unit: Bottle containing 42 film-coated tablets (200 mg strength).
⚠️ APPLICATION INSTRUCTIONS:
- Standard Dosage: 600 mg (three 200 mg tablets) taken orally twice daily. Total daily dose is 1200 mg.
- Administration: Swallow tablets whole with water. Can be taken with or without food. Take at approximately the same time each day. Do not chew, crush, or split.
- ✋ Missed Dose: If a dose is missed by more than 4 hours, skip it. Resume the regular schedule next time. Do not double up.
- 🤮 Vomiting: If vomiting occurs after taking a dose, do not take an additional dose. Wait for the next scheduled dose.
- ⛔ Pregnancy & Breastfeeding: Strictly contraindicated due to fetal toxicity. Effective contraception is mandatory.
- Hypersensitivity to Adagrasib.
- Co-administration with strong CYP3A4 inducers.
- Severe hepatic impairment requires caution.
Regular ECGs and liver function tests are required. Potential side effects include:
- 🤢 Gastrointestinal: Diarrhea (very common), nausea, vomiting. Hydration is important.
- 🔶 Hepatotoxicity: Elevated liver enzymes (ALT/AST).
- ❤️ Cardiac: QTc interval prolongation (heart rhythm changes).
- 🤧 Respiratory: Interstitial Lung Disease (ILD) / Pneumonitis (rare but serious).
- 🩸 Hematologic: Anemia, decreased white blood cell count.
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